Detection of Nucleic Acids with Graphene Nanopores : Ab Ini - tio

Submitted for the MAR10 Meeting of The American Physical Society Detection of Nucleic Acids with Graphene Nanopores: Ab Initio Characterization of a Novel Sequencing Device1 TAMMIE NELSON, BO ZHANG, OLEG PREZHDO, University of Washington — We report an ab initio study of the interaction of two nucleobases, cytosine and adenine, with a novel graphene nanopore device for detecting the base sequence of a single-stranded nucleic acid (ssDNA or RNA). The nucleobases were inserted into a pore in a graphene nanoribbon, and the electrical current and conductance spectra were calculated as functions of voltage applied across the nanoribbon. The conductance spectra and charge densities were analyzed in the presence of each nucleobase in the graphene nanopore. The results indicate that, due to significant differences in the conductance spectra, the proposed device has adequate sensitivity to discriminate between different nucleotides. Moreover, we show that the nucleotide conductance spectra is not affected by its orientation inside the graphene nanopore. The proposed technique may be extremely useful for real applications in developing ultrafast, low cost DNA sequencing methods. 1Authors are grateful to Dr. Bradley F. Habenicht for discussion. Research was supported by grants from NSF and ACS. Tammie Nelson University of Washington Date submitted: 17 Nov 2009 Electronic form version 1.4